Hepatic Lipogenesis Pathway (DNL)

The hepatic lipogenesis pathway is the metabolic route in the liver responsible for synthesizing fatty acids from non-lipid precursors, primarily carbohydrates. This process involves the conversion of acetyl-CoA to malonyl-CoA by acetyl-CoA carboxylase (ACC), followed by the sequential addition of two-carbon units by fatty acid synthase (FASN). The pathway is tightly regulated by transcription factors like SREBP1c and ChREBP, and its dysregulation is implicated in the development of NAFLD, NASH, and other metabolic disorders. Targeting this pathway is a potential therapeutic strategy for managing these conditions.

Other names

De Novo Lipogenesis PathwayFatty Acid Synthesis Pathway (Liver)

Inhibition or modulation of key enzymes in the pathway (e.g., ACC, FASN)