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Hepatocyte regeneration refers to the process by which hepatocytes, the main functional cells of the liver, proliferate to restore liver mass and function following injury or partial hepatectomy[1][3][4]. This regenerative response is regulated by a complex interplay of cellular and molecular mechanisms involving growth factors (such as hepatocyte growth factor (HGF) and transforming growth factor alpha (TGF-α)), cytokines (such as interleukin-6 and tumor necrosis factor alpha), and multiple intracellular signaling pathways including IL-6/STAT3, PI3-K/PDK1/Akt, Wnt/β-catenin, Hippo/YAP, and Notch[1][2][3][4]. The process occurs in three main stages: initiation (priming), proliferation, and termination. Hepatocyte regeneration is critical for liver health, as it allows recovery from a wide range of insults, but it is not itself a single druggable molecular entity or biomarker[1][3][4]. Summary: "Hepatocyte regeneration" describes a cellular repair process and is not a canonical molecular drug target; instead, it encompasses numerous signaling pathways and cell types essential for liver recovery and repair[1][2][3][4].

Other names

Hepatocyte proliferationLiver regenerationCompensatory hepatocyte proliferationHepatic regeneration

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