Hepatic Stellate Cell Proliferation (HSC Proliferation)

Hepatic stellate cell (HSC) proliferation refers to the process by which these liver-resident pericytes increase in number, particularly in response to liver injury or chronic inflammation. HSCs are normally quiescent but become activated and proliferative during liver damage, playing a central role in fibrogenesis and the pathogenesis of cirrhosis and hepatocellular carcinoma (HCC). Key pathways involved include glutamine metabolism and growth factor/cytokine signaling. Targeting these pathways represents promising strategies against liver fibrosis.

Other names

Liver Stellate Cell ProliferationHSC Activation and ProliferationHepatic Fibroblast Proliferation

Inhibition of metabolic enzymes (e.g., glutaminase) or growth factor signaling pathways (e.g., PDGF, TGF-β) to reduce HSC proliferation and ECM production.