Hepatic Triglyceride Lipase (HTGL)

Hepatic triglyceride lipase (HTGL), also known as hepatic lipase (HL) or LIPC, is a key enzyme in lipid metabolism. It catalyzes the hydrolysis of triglycerides, phospholipids, mono-, di-glycerides, and acyl-CoA thioesters present in circulating plasma lipoproteins. HTGL plays an essential role in regulating plasma levels of intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL), very low–density lipoproteins (VLDLs), chylomicron remnants, HDL cholesterol, and phospholipids. Deficiency or mutations in LIPC/HTGL can lead to hepatic lipase deficiency—a disorder characterized by elevated beta-migrating VLDLs and abnormally triglyceride-rich LDLs/HDLs. This may manifest clinically as hypercholesterolemia or hypertriglyceridemia with increased risk for coronary artery disease due to altered lipid profiles.

Other names

HLLIPC

Inhibition of triglyceride hydrolysis in lipoproteins, modulation of lipoprotein particle size and composition.