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Hepatic VLDL Synthesis Pathway (Hepatic VLDL Synthesis)
- Target
- Hepatic VLDL Synthesis
- Molecular classification
- Metabolic Pathway, Lipid Metabolism, Enzyme Cascade
01
Overview
The hepatic VLDL synthesis pathway is a series of biochemical processes in the liver that produce and secrete VLDL particles, rich in triglycerides. Niacin modulates this pathway, leading to decreased VLDL production, lower triglycerides and LDL cholesterol, and increased HDL cholesterol. It acts by inhibiting triglyceride synthesis, reducing free fatty acid delivery to the liver, and increasing apoB degradation.
- Other names
- Hepatic Triglyceride SynthesisHepatic LipogenesisVLDL Production
02
Mechanism of action
Niacin inhibits hepatic diacylglycerol acyltransferase-2, reducing triglyceride synthesis and VLDL production. It also reduces free fatty acid delivery to the liver and accelerates intracellular apoB degradation.
03
Biological functions
Lipid metabolismTriglyceride synthesisVLDL productionCholesterol metabolism
04
Disease associations
HyperlipidemiaCardiovascular diseaseMetabolic syndromeNon-alcoholic fatty liver disease (NAFLD)
05
Safety considerations
FlushingHepatotoxicityInsulin resistanceGastrointestinal discomfort
06
Interacting drugs
Niacin
07
Biomarkers
TriglyceridesVLDL cholesterolLDL cholesterolHDL cholesterolApoBApoA-I
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