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Target intelligence / Profile preview
Hepatitis B Virus Capsid (HBV Capsid)
- Target
- HBV Capsid
- Molecular classification
- Viral protein, Structural protein
01
Overview
The hepatitis B virus (HBV) capsid is a protein shell composed of core protein subunits that forms an icosahedral structure. It encapsulates the viral genome and plays essential roles throughout the HBV life cycle, including genome packaging, reverse transcription, intracellular trafficking, envelopment by surface proteins, and release from infected cells. It is a therapeutic target for small molecules called Capsid Assembly Modulators (CAMs).
- Other names
- HBV Core ParticleHBcAg Capsid
02
Mechanism of action
Disruption of capsid assembly, induction of aberrant capsid structures, inhibition of DNA replication
03
Biological functions
Genome packagingReverse transcriptionIntracellular traffickingEnvelopmentViral assemblyImmune evasion
04
Disease associations
InfectionHepatitis BLiver diseaseHepatocellular carcinoma
05
Safety considerations
Potential for drug resistanceOff-target effects of capsid assembly modulators
06
Interacting drugs
Capsid Assembly Modulators (CAMs)
1 more in the full profile.
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