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Target intelligence / Profile preview
Hepatitis B Virus cccDNA-Derived Transcripts (HBV cccDNA transcripts)
- Target
- HBV cccDNA transcripts
- Molecular classification
- RNA, Viral RNA, mRNA
01
Overview
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA)-derived transcripts are RNA molecules transcribed from the cccDNA minichromosome within infected hepatocytes. These transcripts, including pregenomic RNA (pgRNA), precore RNA, surface antigen RNAs, and X gene RNA, serve as templates for viral protein synthesis and are essential for HBV replication and persistence. They are key biomarkers for monitoring active infection and therapeutic response, and represent therapeutic targets for achieving functional cure.
- Other names
- HBV cccDNA mRNAscccDNA-derived viral RNAHBV pregenomic RNAHBV precore RNAHBV surface antigen RNAsHBV X gene transcript
02
Mechanism of action
HBV antivirals can reduce cccDNA transcription activity or inhibit reverse transcription of pgRNA.
03
Biological functions
Viral replicationViral protein synthesisGene expressionTemplate for translationImmune evasion
04
Disease associations
Hepatitis BChronic HBV infectionHepatocellular carcinoma
05
Safety considerations
Drug resistanceReactivation of HBV infectionLimited efficacy in cccDNA eradicationSide effects of antiviral therapies
06
Interacting drugs
Interferon-alpha
3 more in the full profile.
07
Biomarkers
HBV RNA levelsHBsAg levelscccDNA levelsHBV DNA levels
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