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Target intelligence / Profile preview
Hepatitis B Virus Core Protein (HBc)
- Target
- HBc
- Molecular classification
- Viral protein, Structural protein
01
Overview
The hepatitis B virus (HBV) core protein, often referred to as HBc or Cp, is a multifunctional viral protein that plays essential roles throughout the HBV life cycle. It is the primary structural component of the viral nucleocapsid and is crucial for viral replication, genome packaging, and interaction with host cell machinery. It is considered an attractive antiviral target because it has no human homologs. Small molecules known as Core Allosteric Modulators (CAMs) can disrupt proper capsid assembly or function.
- Other names
- Hepatitis B virus core antigenHBcAgCp
02
Mechanism of action
Disruption of capsid assembly or function
03
Biological functions
Capsid assemblyGenome packagingRegulation of replicationNuclear-cytoplasmic shuttlingHost interactionImmune evasion
04
Disease associations
InfectionHepatitis B
05
Safety considerations
PharmacokineticsSafety profiles of CAMs require further optimization
06
Interacting drugs
BAY 41–4109
2 more in the full profile.
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