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Target intelligence / Profile preview
Hepatitis B Virus DNA (HBV DNA)
- Target
- HBV DNA
- Molecular classification
- Viral Genome, Nucleic Acid
01
Overview
Hepatitis B virus (HBV) DNA is the genetic material of the hepatitis B virus, a partially double-stranded, circular DNA molecule approximately 3.2 kilobases in length. This viral genome is encapsidated within the nucleocapsid and plays a central role in HBV replication, infection, and pathogenesis. Detection and quantification of HBV DNA in serum are reliable markers of active viral replication and are used to monitor response to antiviral therapy. The persistence of nuclear cccDNA underlies chronicity and therapeutic challenges associated with hepatitis B virus infections.
02
Mechanism of action
Inhibition of HBV DNA polymerase/reverse transcriptase
03
Biological functions
Viral ReplicationViral Gene ExpressionTemplate for transcriptionReverse transcription
04
Disease associations
Hepatitis BChronic Hepatitis BLiver disease progression
05
Safety considerations
Drug resistanceReactivation of HBV upon treatment cessationPersistence of cccDNALimited efficacy in cccDNA eradication
06
Interacting drugs
Entecavir
3 more in the full profile.
07
Biomarkers
HBV DNA levels (serum)HBsAgHBeAg
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