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Target intelligence / Profile preview
Hepatitis B virus DNA replication (HBV DNA replication)
- Target
- HBV DNA replication
- Molecular classification
- Viral replication process, Reverse transcription
01
Overview
Hepatitis B virus (HBV) DNA replication is a unique process involving reverse transcription of an RNA intermediate. It begins with the conversion of relaxed circular DNA (rcDNA) to covalently closed circular DNA (cccDNA) in the hepatocyte nucleus. The cccDNA serves as a template for viral mRNA synthesis, including pregenomic RNA (pgRNA). The pgRNA is reverse transcribed by the viral polymerase into rcDNA within newly formed nucleocapsids. This replication cycle ensures persistent infection and virion production. Approved antiviral drugs primarily target the reverse transcriptase activity, inhibiting viral DNA synthesis but not eliminating the cccDNA reservoir.
02
Mechanism of action
Inhibition of reverse transcriptase activity
03
Biological functions
Viral genome replicationVirion productionEstablishment of persistent infection
04
Disease associations
Chronic hepatitis BLiver cirrhosisHepatocellular carcinoma
05
Safety considerations
Drug resistanceIncomplete viral suppressionReactivation of HBV upon drug cessation
06
Interacting drugs
Entecavir
4 more in the full profile.
07
Biomarkers
HBV DNA levelsHBeAgHBsAg
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