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Target intelligence / Profile preview
Hepatitis B Virus Particle (HBV virion)
- Target
- HBV virion
- Molecular classification
- Virus, Enveloped Virus, DNA Virus
01
Overview
The hepatitis B virus (HBV) particle, or Dane particle, is the infectious form of HBV. It is a ~42 nm spherical, enveloped DNA virus that infects liver cells. The envelope contains HBsAg (S, M, L proteins), surrounding an icosahedral nucleocapsid (HBcAg) containing the partially double-stranded circular DNA genome and viral polymerase. The virion functions to deliver its genome into host hepatocytes for replication. HBsAg mediates attachment to hepatocytes via NTCP receptors. Subviral particles composed only of HBsAg are also produced and act as decoys for neutralizing antibodies.
- Other names
- Dane particleComplete Hepatitis B Virus
02
Mechanism of action
Reverse transcriptase inhibitors block viral DNA synthesis; Interferon alpha stimulates the immune system to clear the virus.
03
Biological functions
Viral replicationHost cell entryGenome deliveryImmune evasion
04
Disease associations
InfectionHepatitis BLiver cirrhosisHepatocellular carcinoma
05
Safety considerations
Drug resistanceAdverse effects of antiviral medicationsReactivation of HBV infectionDevelopment of hepatocellular carcinoma
06
Interacting drugs
Entecavir
5 more in the full profile.
07
Biomarkers
HBsAgHBeAgHBV DNA viral load
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