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Target intelligence / Profile preview
Hepatitis B Virus Polymerase Protein (Pol)
- Target
- Pol
- Molecular classification
- Enzyme, Reverse Transcriptase, Polymerase, RNase H
01
Overview
The Hepatitis B virus (HBV) polymerase, also known as Pol or P protein, is a multifunctional enzyme essential for the replication of HBV. It converts the viral pre-genomic RNA (pgRNA) into partially double-stranded relaxed circular DNA (rcDNA) within newly formed viral capsids. It possesses reverse transcriptase and RNase H activity. The polymerase is a major target for antiviral drugs like entecavir and tenofovir. Resistance mutations can arise due to error-prone viral replication.
- Other names
- P proteinHBV polymeraseHBV DNA polymerase
02
Mechanism of action
Inhibition of reverse transcriptase activity, leading to termination of DNA chain elongation
03
Biological functions
Reverse transcriptionViral genome replicationRNA degradationDNA synthesisImmune evasionProtein priming
04
Disease associations
Hepatitis BChronic HBV infectionLiver cirrhosisHepatocellular carcinoma
05
Safety considerations
Development of drug resistance mutationsLimited efficacy in some patients
06
Interacting drugs
Entecavir
1 more in the full profile.
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