Target intelligence / Profile preview

Hepatitis B virus pre-S2 antigen (pre-S2)

Target: pre-S2
Molecular classification: Viral protein, Envelope glycoprotein, Antigen

Overview

The hepatitis B pre-S2 antigen is a domain within the envelope proteins of the hepatitis B virus (HBV). It is part of the large (LHBs) and middle (MHBs) surface antigens. The pre-S2 domain is 55 amino acids long and plays a crucial role in virion assembly and contributes to viral entry. Its detection in serum serves as a marker for HBV infection.

Other names: HBV pre-S2 antigenpreS2 domainMiddle HBsAg subunitLarge HBsAg subunit

Biological functions

Virion assemblyViral entry (supportive)Immunogenicity

Disease associations

Hepatitis B infectionLiver disease

Biomarkers

HBsAg positivityPre-S2 antigen presence in serum

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