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Target intelligence / Profile preview
Hepatitis B virus preS protein (preS)
- Target
- preS
- Molecular classification
- Viral protein, Surface antigen, Envelope protein
01
Overview
The Hepatitis B virus (HBV) preS protein refers to the preS1 and preS2 domains found in the large and middle surface proteins of HBV, which are critical for viral infectivity, host cell entry, immune recognition, and vaccine design. The preS1 domain contains the receptor-binding site essential for attachment to hepatocytes via interaction with NTCP. Both preS1 and preS2 contain immunogenic T-cell and B-cell epitopes, making them targets for vaccine development and diagnostic applications. Myrcludex B is an example of a drug that targets the preS1 domain to inhibit viral entry.
- Other names
- preS1 domainpreS2 domainLarge surface protein preS domain (L-HBs preS)Middle surface protein preS domain (M-HBs preS)
02
Mechanism of action
NTCP binding inhibition
03
Biological functions
Host cell receptor bindingVirion assemblyImmune response elicitationViral entry
04
Disease associations
Hepatitis B virus infectionLiver disease
05
Safety considerations
Potential for immune escape with mutationsVariability in preS1 sequence across HBV genotypes
06
Interacting drugs
Myrcludex B
07
Biomarkers
Antibodies against pre-S domains
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