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Target intelligence / Profile preview
Hepatitis B Virus Reverse Transcriptase (HBV RT)
- Target
- HBV RT
- Molecular classification
- Enzyme, Reverse Transcriptase
01
Overview
Hepatitis B virus (HBV) reverse transcriptase, also known as the viral polymerase or P protein, is a multifunctional enzyme essential for HBV replication. It catalyzes the reverse transcription of pregenomic RNA (pgRNA) into relaxed circular DNA (rcDNA), a unique process among DNA viruses and central to the HBV life cycle. It possesses RNA-dependent DNA polymerization, DNA-dependent DNA polymerization, RNase H activity, and protein priming functions. It is a major target for antiviral drugs used to treat chronic hepatitis B.
- Other names
- HBV PolymeraseP proteinPol
02
Mechanism of action
Inhibition of viral DNA strand elongation by nucleos(t)ide analogs.
03
Biological functions
Reverse transcriptionRNA-dependent DNA polymerizationDNA-dependent DNA polymerizationRNase H activityProtein priming
04
Disease associations
InfectionHepatitis BChronic Hepatitis B
05
Safety considerations
Drug resistance mutationsLong-term toxicity
06
Interacting drugs
Nucleos(t)ide analogs (e.g., Tenofovir, Entecavir)
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