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Target intelligence / Profile preview
Hepatitis B virus S open reading frame (HBV S ORF)
- Target
- HBV S ORF
- Molecular classification
- Viral protein, Envelope protein
01
Overview
The Hepatitis B virus S open reading frame (HBV S ORF) encodes the surface antigens of the hepatitis B virus (HBV), which are critical for viral infectivity, immune recognition, and serve as key diagnostic and vaccine targets. It encodes three related envelope proteins: Large (L), Middle (M), and Small (S) also known as hepatitis B surface antigen (HBsAg).
- Other names
- pre-S/S open reading frameSurface antigenHBsAgLarge (L) proteinMiddle (M) proteinSmall (S) protein
02
Mechanism of action
The Hepatitis B vaccine elicits an antibody response to HBsAg, providing protection against HBV infection.
03
Biological functions
Viral entryImmune recognitionEnvelope formation
04
Disease associations
InfectionHepatitis BLiver disease
05
Safety considerations
Mutations in the S ORF can lead to immune escape and vaccine failure.
06
Interacting drugs
Hepatitis B vaccine
07
Biomarkers
HBsAg
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