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Target intelligence / Profile preview
Hepatitis C Virus Antigen (None)
- Target
- None
- Molecular classification
- Viral protein, Structural protein, Non-structural protein
01
Overview
Hepatitis C virus (HCV) antigens are viral proteins produced during HCV infection that are recognized by the host immune system. The most clinically relevant antigen is the HCV core antigen (HCV-cAg), a marker of active viral replication. Other structural proteins, such as envelope glycoproteins E1 and E2, also serve as important antigens and are targets for neutralizing antibodies. Detection of HCV antigens, particularly the core antigen, is used in diagnostics to confirm active infection and monitor treatment response.
- Other names
- HCV AntigenHCV Core AntigenHCV-cAgEnvelope glycoprotein E1Envelope glycoprotein E2
02
Mechanism of action
N/A
03
Biological functions
Viral replicationCapsid formationCell entryImmune response elicitation
04
Disease associations
InfectionHepatitis CChronic liver disease
05
Safety considerations
Antigenic variation (affects antibody binding)Hypervariable region 1 (HVR1) shields epitopes from neutralizing antibodies
06
Biomarkers
HCV core antigen level (diagnosis, treatment monitoring)Anti-HCV antibody (past or current infection)
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