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Target intelligence / Profile preview
Hepatitis C virus Envelope Glycoprotein E2
- Molecular classification
- Viral Envelope Protein, Glycoprotein
01
Overview
The Hepatitis C virus (HCV) E2 glycoprotein is a major envelope protein found on the surface of HCV particles. It plays a central role in viral entry into host cells by interacting with cellular receptors such as CD81. E2 forms a heterodimer with E1, essential for viral attachment and membrane fusion. It is a primary target for neutralizing antibodies, making it a key focus for vaccine and therapeutic development. The protein exhibits high flexibility and intrinsic disorder, conserved across different HCV strains, posing challenges for targeted therapies.
- Other names
- HCV E2E2 glycoprotein
02
Mechanism of action
Neutralization of viral entry by blocking receptor binding or fusion.
03
Biological functions
Viral entryReceptor bindingMembrane fusionImmune evasion
04
Disease associations
InfectionHepatitis C
05
Safety considerations
High genetic variability leading to immune escapeGlycosylation hindering antibody binding
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