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Target intelligence / Profile preview
Hepatitis C Virus Non-Structural Protein 5A (NS5A)
- Target
- NS5A
- Molecular classification
- Viral protein, Phosphoprotein
01
Overview
Hepatitis C virus nonstructural protein 5A (NS5A) is an essential regulatory factor orchestrating multiple steps in the HCV life cycle—including genome amplification, particle production/assembly—and modulating diverse cellular responses relevant to pathogenesis. Its centrality makes it an important drug target against hepatitis C infection.
02
Mechanism of action
Inhibition of viral replication and assembly by binding to NS5A protein.
03
Biological functions
Viral replicationVirion assemblyModulation of host cell signalingRNA binding
04
Disease associations
InfectionLiver disease progression
05
Safety considerations
Drug resistanceDrug-drug interactions
06
Interacting drugs
NS5A inhibitors (e.g., Ledipasvir, Daclatasvir, Ombitasvir, Elbasvir, Velpatasvir)
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