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Target intelligence / Profile preview
Hepatitis C virus non-structural protein 5B (NS5B)
- Target
- NS5B
- Molecular classification
- Enzyme, RNA-dependent RNA polymerase, Viral protein
01
Overview
Hepatitis C virus non-structural protein 5B (NS5B) is an RNA-dependent RNA polymerase (RdRp) essential for HCV genome replication. It catalyzes the synthesis of new viral RNA strands, making it a prime target for antiviral drugs. Its structure, resembling a right hand, contains a unique active site in the palm domain. NS5B interacts with other viral and host proteins, influencing replication efficiency. Inhibitors target either the active site (nucleotide analogs) or allosteric sites (non-nucleoside inhibitors) to disrupt its polymerase function.
- Other names
- HCV NS5BNS5B RNA-dependent RNA polymeraseHepatitis C Virus RNA-dependent RNA polymerase
02
Mechanism of action
Inhibition of viral RNA-dependent RNA polymerase activity
03
Biological functions
Viral RNA replicationRNA synthesisGenome replication
04
Disease associations
InfectionHepatitis C
05
Safety considerations
Drug resistanceOff-target effectsViral mutations
06
Interacting drugs
Sofosbuvir
6 more in the full profile.
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