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Target intelligence / Profile preview
Hepatitis C virus Nonstructural Protein 3-4A Protease (HCV NS3/4A protease)
- Target
- HCV NS3/4A protease
- Molecular classification
- Enzyme, Serine protease
01
Overview
The Hepatitis C virus (HCV) NS3/4A protease is a membrane-associated, chymotrypsin-like serine protease essential for the viral life cycle. It cleaves the HCV polyprotein at multiple sites, generating mature viral proteins required for replication. It also disrupts host innate immunity by cleaving key signaling proteins like TRIF and MAVS. Due to its critical role, it is a major target for direct-acting antiviral drugs.
- Other names
- HCV NS3/4ANS3-4A proteaseNS3/4A serine proteaseHepatitis C virus NS3/4A serine protease
02
Mechanism of action
Competitive inhibition of NS3/4A protease activity, preventing viral polyprotein processing
03
Biological functions
Viral polyprotein processingViral replicationImmune evasionEndopeptidase activity
04
Disease associations
InfectionHepatitis C
05
Safety considerations
Potential for drug resistance mutationsDrug-drug interactionsHepatotoxicity
06
Interacting drugs
Grazoprevir
3 more in the full profile.
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