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Target intelligence / Profile preview
Hepatitis C Virus Nonstructural Protein 3 Protease (HCV NS3/4A)
- Target
- HCV NS3/4A
- Molecular classification
- Viral protein, Enzyme, Serine protease
01
Overview
The Hepatitis C virus (HCV) nonstructural protein 3 protease, commonly referred to as NS3 protease, is a multifunctional viral enzyme essential for HCV replication and maturation. The primary role of the NS3/NS4A complex is to cleave specific sites within the HCV polyprotein at junctions between nonstructural proteins: specifically at NS3/NS4A, NS4A/NS4B, NS4B/NS5A, and NS5A/NS5B sites. As an essential enzyme for HCV life cycle progression, the HCV NS3/NS4A protease has been established as one of the most attractive targets for anti-HCV drug development.
- Other names
- HCV NS3 proteaseNS3 proteaseHCV NS3NS3/4A protease
02
Mechanism of action
Inhibition of NS3/4A protease activity, thereby blocking viral polyprotein processing and replication.
03
Biological functions
Viral polyprotein processingViral replicationMaturation of viral proteins
04
Disease associations
InfectionHepatitis C
05
Interacting drugs
Boceprevir
4 more in the full profile.
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