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Target intelligence / Profile preview
Hepatitis C Virus Nonstructural Protein 5A (NS5A)
- Target
- NS5A
- Molecular classification
- Viral protein, Phosphoprotein
01
Overview
Hepatitis C virus nonstructural protein 5A (NS5A) is a multifunctional, zinc-binding, proline-rich hydrophilic phosphoprotein essential for the life cycle of the hepatitis C virus (HCV). NS5A plays critical roles in viral RNA replication, assembly of new virions, modulation of host cell signaling pathways, and pathogenesis. It is targeted by direct acting antiviral agents known as "NS5A inhibitors."
02
Mechanism of action
Inhibition of NS5A protein function, leading to disruption of viral RNA replication and virion assembly.
03
Biological functions
Viral RNA replicationVirion assemblyModulation of host cell signalingRegulation of genome replication
04
Disease associations
InfectionLiver pathogenesisHepatitis C
05
Safety considerations
Resistance mutations affecting drug efficacy
06
Interacting drugs
NS5A inhibitors
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