Target intelligence / Profile preview

Hepatitis C Virus Nonstructural Protein 5B (NS5B)

Target: NS5B
Molecular classification: Enzyme, RNA-dependent RNA polymerase

Overview

NS5B is a nonstructural protein encoded by the hepatitis C virus (HCV). It functions as an RNA-dependent RNA polymerase (RdRp), which is essential for viral RNA replication. NS5B catalyzes the polymerization of ribonucleoside triphosphates (rNTPs) using the viral positive-sense RNA strand as a template, enabling synthesis of new viral genomes. It is a major target for antiviral drugs.

Mechanism of action

Inhibition of viral RNA-dependent RNA polymerase activity

Biological functions

Viral RNA replication

Disease associations

InfectionHepatitis C

Safety considerations

Potential for drug resistanceDrug-drug interactions

Interacting drugs

Sofosbuvir

6 more in the full profile.

Beyond the preview

Go deeper on Hepatitis C Virus Nonstructural Protein 5B (NS5B).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Hepatitis C Virus Nonstructural Protein 5B (NS5B).

Explore the full profile