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Target intelligence / Profile preview
Hepatitis C virus NS3-NS4A serine protease (NS3/4A protease)
- Target
- NS3/4A protease
- Molecular classification
- Enzyme, Serine protease, Viral protein
01
Overview
The Hepatitis C virus NS3-NS4A serine protease is a membrane-associated, non-covalent heterodimeric complex essential for HCV replication. It functions to cleave the viral polyprotein at multiple sites, releasing mature viral proteins. Its role in both viral replication and immune evasion makes it a prime target for antiviral drug development. Approved drugs like boceprevir, telaprevir, and paritaprevir specifically inhibit its proteolytic function, leading to significant improvements in treatment outcomes for chronic hepatitis C patients.
- Other names
- HCV NS3/4A proteaseNS3 serine proteaseNS3-4A protease complex
02
Mechanism of action
Inhibition of viral protease activity, preventing polyprotein processing and viral replication.
03
Biological functions
Viral polyprotein processingViral replicationInnate immune evasion
04
Disease associations
InfectionHepatitis CLiver disease
05
Interacting drugs
Boceprevir
2 more in the full profile.
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