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Target intelligence / Profile preview
Hepatitis C virus NS5 protein
- Molecular classification
- Viral protein, RNA-dependent RNA polymerase (NS5B), Phosphoprotein (NS5A)
01
Overview
The Hepatitis C virus (HCV) nonstructural protein 5 (NS5) region encodes two distinct proteins: NS5A and NS5B. Both proteins are essential for viral replication and pathogenesis. NS5A is a multifunctional regulator involved in viral replication complex assembly and immune evasion. NS5B is an RNA-dependent RNA polymerase that catalyzes the synthesis of new HCV RNA strands. Both proteins are directly targeted by direct acting antivirals (DAAs).
- Other names
- NS5HCV NS5NS5ANS5B
02
Mechanism of action
NS5A inhibitors disrupt viral replication complex assembly and virion assembly; NS5B inhibitors block RNA-dependent RNA polymerase activity.
03
Biological functions
Viral genome replicationViral assemblyImmune evasionModulation of cell signaling pathways
04
Disease associations
InfectionHepatitis CLiver fibrosisHepatocellular carcinoma
05
Safety considerations
Drug resistanceDrug-drug interactionsReactivation of Hepatitis B virus (HBV)
06
Interacting drugs
NS5A inhibitors (e.g., Ledipasvir, Daclatasvir, Velpatasvir)
1 more in the full profile.
07
Biomarkers
HCV RNA levelsHCV genotypeInterferon sensitivity determining region (ISDR) mutations
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