Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Hepatitis C Virus RNA-Dependent RNA Polymerase (HCV RdRp)
- Target
- HCV RdRp
- Molecular classification
- Enzyme, Polymerase, RNA-dependent RNA polymerase
01
Overview
The hepatitis C virus RNA-dependent RNA polymerase, commonly referred to as NS5B, is a viral enzyme essential for the replication of the HCV genome. It catalyzes the synthesis of new viral RNA strands using an existing RNA template, a process central to the life cycle of HCV and a key target for antiviral drug development. NS5B operates within a multi-protein replication complex that includes other nonstructural proteins and host factors. Due to its essential role in viral replication and absence from uninfected human cells, HCV RdRp/NS5B has been extensively targeted by direct acting antivirals (DAAs).
- Other names
- NS5BNonstructural protein 5BHCV NS5B polymerase
02
Mechanism of action
Chain termination (nucleoside analogs) and non-nucleoside inhibition of polymerase activity
03
Biological functions
Viral RNA replicationRNA synthesis
04
Disease associations
InfectionHepatitis C
Beyond the preview
Go deeper on Hepatitis C Virus RNA-Dependent RNA Polymerase (HCV RdRp).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Hepatitis C Virus RNA-Dependent RNA Polymerase (HCV RdRp).