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Target intelligence / Profile preview
Hepatitis C Virus RNA Polymerase NS5B (NS5B)
- Target
- NS5B
- Molecular classification
- Enzyme, RNA-dependent RNA polymerase
01
Overview
The hepatitis C virus RNA polymerase, also known as NS5B, is a nonstructural protein that functions as an RNA-dependent RNA polymerase (RdRp). It is essential for the replication of the HCV genome and is a primary target for direct-acting antiviral drugs.
- Other names
- Nonstructural protein 5BHCV RNA-dependent RNA polymeraseRdRp NS5B
02
Mechanism of action
Nucleoside inhibitors mimic natural substrates and cause chain termination. Nonnucleoside inhibitors bind allosteric sites and cause conformational changes that inhibit activity.
03
Biological functions
Viral genome replicationRNA synthesis
04
Disease associations
InfectionHepatitis C
05
Safety considerations
Resistance-associated variants
06
Interacting drugs
Nucleoside inhibitors (NIs)
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