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Target intelligence / Profile preview
Hepatitis D Virion (HDV)
- Target
- HDV
- Molecular classification
- Virus, Satellite Virus, RNA Virus
01
Overview
The hepatitis D virion (HDV) is a defective RNA virus that requires hepatitis B virus (HBV) for its replication and assembly. It consists of a ribonucleoprotein core containing the viral genome and hepatitis delta antigen (HDAg), surrounded by an envelope derived from HBV surface antigens. HDV cannot replicate independently and relies on HBV for its propagation. Therefore, targeting HBV replication indirectly inhibits HDV. Bulevirtide targets NTCP to block entry of both HBV and HDV.
- Other names
- Hepatitis Delta VirusHD virion
02
Mechanism of action
N/A - HDV is not a direct drug target, but drugs targeting HBV replication or entry affect it indirectly. Bulevirtide directly blocks HDV entry.
03
Biological functions
Viral ReplicationInfectivityGenome PackagingCell Entry
04
Disease associations
Hepatitis DLiver DamageHepatocellular Carcinoma (associated)
05
Safety considerations
Liver inflammationDisease progressionDrug resistance (to indirectly acting therapies)
06
Interacting drugs
Interferon alpha (effects on HBV replication can indirectly impact HDV)
2 more in the full profile.
07
Biomarkers
HDV RNA levels (viral load)Hepatitis D antigen (HDAg)Anti-HDV antibodies
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