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Target intelligence / Profile preview
Hepatitis E Virus ORF2 Capsid Protein (ORF2)
- Target
- ORF2
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The ORF2 protein is the major capsid protein of the hepatitis E virus (HEV). It is encoded by the second open reading frame (ORF2) of the HEV genome and plays a central role in viral structure, infectivity, immune evasion, and host interaction. It forms an icosahedral capsid and exists in various isoforms, including an infectious capsid-associated form, a glycosylated secreted form, and a cleaved secreted form. ORF2 interacts with host cell receptors such as heparan sulfate proteoglycans and ASGR1/ASGR2 to facilitate viral entry. It also modulates the host immune response. ORF2 contains neutralizing epitopes and is a promising candidate for subunit vaccine development and is also a diagnostic target in ELISA assays to detect acute versus chronic infections.
- Other names
- HEV capsid proteinORF2 proteinHEV ORF2Hepatitis E virus capsid proteinHEV ORF2 capsid protein
02
Mechanism of action
N/A
03
Biological functions
Virion assemblyGenome encapsidationCell receptor bindingViral entryImmune modulationHost interaction
04
Disease associations
Hepatitis EAcute hepatitisChronic hepatitisViral infection
05
Safety considerations
Potential for immune escape due to glycosylation variationsRisk of severe outcomes in pregnant women and immunocompromised individualsPossible development of chronic infection in immunocompromised patients
06
Biomarkers
Anti-HEV antibodiesHEV RNA
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