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Hepatitis E Virus ORF2 Capsid Protein (Amino Acids 368–606) (HEV ORF2 (368-606))
- Target
- HEV ORF2 (368-606)
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The ORF2 protein of the hepatitis E virus (HEV) is the major capsid protein. The region spanning amino acids 368–606 covers part of the middle domain and most or all of the protruding domain, which are critical for host cell interaction and immune recognition. It is a prime target for diagnostic assays and vaccine development efforts due to the presence of neutralizing B-cell epitopes.
- Other names
- HEV Capsid Protein (368-606)ORF2 protein fragment (368-606)HEV ORF2HEV P domain
02
Mechanism of action
Neutralization of viral entry; inhibition of capsid assembly (potential)
03
Biological functions
Capsid assemblyRNA encapsidationHost cell attachmentImmune evasionViral entry
04
Disease associations
InfectionHepatitis E
05
Safety considerations
Potential for immune escape due to sequence variabilityNeed for broad coverage against different HEV genotypes
06
Biomarkers
Antibody detection for HEV diagnosisPresence of ORF2-specific antibodies as correlate of protection
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