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Hepatobiliary system
- Molecular classification
- Other (anatomical system)
01
Overview
The hepatobiliary system is the anatomical and functional unit comprising the liver, gallbladder, and bile ducts. It is responsible for the production, storage, and secretion of bile, a fluid essential for fat digestion and the excretion of waste products. The liver synthesizes bile, the gallbladder stores it, and the bile ducts transport it to the small intestine. Disorders of the hepatobiliary system are common and can include cancer, infection, inflammation, and bile duct obstruction. While various drugs may affect the function of this system or treat diseases within it, the "hepatobiliary system" is not itself a classical therapeutic target[1][3][4][5][6][7].
- Other names
- Biliary systemBiliary tract
02
Biological functions
Bile productionBile storageBile secretionFat digestionWaste elimination
03
Disease associations
Cancer (e.g., liver cancer, bile duct cancer)Inflammation (e.g., hepatitis, cholangitis)Infection (e.g., hepatitis viruses, bacterial cholangitis)GallstonesOther (e.g., biliary atresia, cirrhosis)
04
Safety considerations
Organ toxicity (e.g., hepatotoxicity from various drugs)JaundiceCholestasisBiliary obstruction
05
Biomarkers
Liver enzymes (e.g., AST, ALT)BilirubinAlkaline phosphataseGamma-glutamyltransferase (GGT)
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