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Hepatocellular carcinoma, down-regulated 1 (HEPN1)

Target: HEPN1
Molecular classification: Other (protein coding gene; not enzyme, receptor, transporter, or typical drug target class)

Overview

Hepatocellular carcinoma, down-regulated 1 (HEPN1) is a short peptide encoded by the HEPN1 gene, mainly expressed in the liver. HEPN1 appears to function as a growth suppressor: its expression inhibits cell growth and promotes apoptosis in liver cancer cells. In hepatocellular carcinoma, HEPN1 expression is frequently lost or substantially reduced, implicating it as a putative tumor suppressor and suggesting that its silencing may play a role in liver cancer development. The gene is located in the 3'-noncoding region of HEPACAM, on the antisense strand. It does not belong to any major drug-targeted molecular family and is currently not regarded as a direct therapeutic target.

Other names: Hepatocellular carcinoma, down-regulated 1Putative cancer susceptibility gene HEPN1 proteinCancer susceptibility gene HEPN1HEPACAM opposite strand 1

Mechanism of action

None known (no current drugs target HEPN1)

Biological functions

Cell growth inhibitionApoptosis inductionPossibly involved in cell cycle regulation

Disease associations

Cancer (down-regulated or silenced in hepatocellular carcinoma and possibly involved in hepatocyte carcinogenesis)

Safety considerations

None documented (therapeutic targeting not established; no drugs or interventions currently known for HEPN1)

Biomarkers

Loss or downregulation of HEPN1 mRNA/protein expression may serve as a biomarker for hepatocellular carcinoma

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