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Hepatocyte Bile Acid Transporter System (HBAT)
- Target
- HBAT
- Molecular classification
- Transporter System, Membrane Transporter, Solute Carrier Family (SLC), ATP-Binding Cassette Transporter (ABC)
01
Overview
The hepatocyte bile acid transporter system is a complex network of membrane proteins responsible for the uptake, intracellular trafficking, and efflux of bile acids in liver cells. This system is crucial for maintaining enterohepatic circulation, facilitating lipid digestion, and regulating cholesterol homeostasis. Key transporters include NTCP (SLC10A1) for sodium-dependent uptake, OATPs (SLCO family) for sodium-independent uptake, and BSEP (ABCB11) for ATP-dependent export into bile. Dysregulation of this system can lead to cholestasis and liver injury.
- Other names
- Hepatocyte Bile Acid TransportHepatic Bile Acid TransportersBile Acid Transporter System (Hepatocyte)Bile Acid Uptake and Efflux in Hepatocytes
02
Mechanism of action
Modulation of bile acid transport, inhibition or induction of transporter expression/activity
03
Biological functions
Bile acid transportEnterohepatic circulation of bile acidsLipid digestion and absorptionCholesterol homeostasisBiliary excretionRegulation of bile acid synthesis
04
Disease associations
CholestasisLiver injuryDrug-induced liver injury (DILI)Biliary disease
05
Safety considerations
Drug-drug interactions affecting bile acid transportHepatotoxicity due to bile acid accumulationCholestasisLiver damage
06
Interacting drugs
Rifampicin
3 more in the full profile.
07
Biomarkers
Serum bile acid levelsBile acid compositionExpression levels of NTCP, OATPs, BSEP, MRP2, MDR1Genetic variations in SLC10A1, SLCO family, ABCB11, ABCC2, ABCB1
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