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Hepatocyte Cell Membrane

Molecular classification: Cell Membrane, Lipid Bilayer, Phospholipid membrane, Biological membrane

Overview

The hepatocyte cell membrane is the plasma membrane of liver cells, essential for maintaining cell polarity and functions like metabolism, secretion, detoxification, and intercellular communication. It comprises apical (canalicular) and basolateral (sinusoidal) domains, each with specialized transporters and receptors. The apical domain is involved in bile secretion, while the basolateral domain handles nutrient uptake and waste removal. The membrane's lipid composition, rich in polyunsaturated fatty acids, makes it vulnerable to oxidative damage, impacting fluidity and function in liver diseases.

Other names: Liver cell membraneHepatocyte plasma membrane

Biological functions

Cell signalingTransportSecretionEndocytosisDetoxificationIntercellular communicationFiltering

Disease associations

HepatitisCirrhosisLiver cancerLiver diseaseOxidative stress related diseases

Safety considerations

Susceptibility to oxidative damage through lipid peroxidationImpaired membrane fluidity and permeability

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