Hepatocyte Function Restoration (None)

Hepatocyte function restoration refers to the process of recovering or enhancing the physiological activities of hepatocytes, the main functional cells of the liver. This target is a therapeutic goal involving multiple molecular pathways, cell types, and regenerative mechanisms that collectively restore lost or impaired liver function due to injury, disease, or surgical resection. Approaches include stimulating endogenous regeneration via growth factors/cytokines, cell-based therapies involving transplantation of primary human/mouse hepatocytes or induced pluripotent stem cell-derived/hepatocyte-like cells, and direct lineage reprogramming.

Stimulating endogenous regeneration via growth factors/cytokines; Cell-based therapies involving transplantation; Direct lineage reprogramming