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Target intelligence / Profile preview
Hepatocyte Growth Factor (HGF)
- Target
- HGF
- Molecular classification
- Growth Factor, Cytokine, Serine Protease-like (inactive)
01
Overview
Hepatocyte growth factor (HGF), also known as scatter factor (SF), is a pleiotropic, paracrine cellular growth factor primarily secreted by mesenchymal stromal cells. It acts on a variety of target cells and is best known for its roles in embryonic organ development, adult organ regeneration, wound healing, angiogenesis, and tumorigenesis. HGF binds to the c-Met receptor tyrosine kinase, triggering downstream signaling cascades that promote cell proliferation, motility, and morphogenesis. It is implicated in cancer progression and metastasis but also shows promise in tissue regeneration therapies.
- Other names
- Scatter FactorSFPro-HGF
02
Mechanism of action
HGF binds to the c-Met receptor tyrosine kinase, triggering dimerization and autophosphorylation of c-Met, leading to downstream signaling cascades that promote cell proliferation, motility, and morphogenesis.
03
Biological functions
Cell proliferationCell motilityMorphogenesisAngiogenesisTissue regenerationEmbryonic development
04
Disease associations
Cancer progressionTumor metastasisLiver regenerationTissue repair
05
Safety considerations
Potential for promoting tumor growth and metastasisOff-target effects due to pleiotropic activity
06
Biomarkers
HGF expression levels in tumorsc-Met expression levels in tumorsHGF serum levels
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