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Hepatocyte Growth Factor Pathway (HGF Pathway)
- Target
- HGF Pathway
- Molecular classification
- Signaling pathway
01
Overview
The hepatocyte growth factor (HGF) pathway is a critical signaling cascade involved in regulating cell growth, motility, morphogenesis, and survival. HGF acts primarily through its receptor, c-Met (also known as the MET proto-oncogene), which is a transmembrane receptor tyrosine kinase. This pathway plays essential roles in embryonic development, tissue regeneration after injury, wound healing, and has significant implications in cancer biology due to its involvement in cell proliferation and migration.
- Other names
- Scatter Factor PathwayHGF/c-Met Pathway
02
Mechanism of action
Various, depending on the specific drug targeting the pathway. Examples include inhibition of c-Met tyrosine kinase activity.
03
Biological functions
Cell growthCell motilityMorphogenesisCell survivalTissue regenerationWound healingAngiogenesisEpithelial-mesenchymal transition
04
Disease associations
CancerLiver diseaseDevelopmental disorders
05
Safety considerations
On-target toxicities due to HGF pathway inhibition in normal tissuesPotential for drug resistance through pathway mutations or bypass mechanismsHepatotoxicity
06
Interacting drugs
c-Met inhibitors (e.g., Cabozantinib, Crizotinib, Tepotinib)
07
Biomarkers
c-Met expression levelsHGF expression levelsPhosphorylated c-MetDownstream signaling molecules (e.g., p-Akt, p-MAPK)
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