Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS)

Hepatocyte growth factor-regulated tyrosine kinase substrate (**HGS**, also known as **HRS**) is a cytosolic protein encoded by the HGS gene in humans. It is a central component of the ESCRT-0 complex involved in intracellular signal transduction and vesicular trafficking, particularly for cytokine and growth factor receptors. HGS functions to recognize and sort ubiquitinated membrane proteins for degradation by lysosomes and is essential for the formation and function of multivesicular bodies (MVBs) in endosomal pathways. It is implicated in regulating receptor tyrosine kinase downregulation, modulating MAP kinase signaling, and the recycling of cell surface receptors. HGS participates in multiple cellular processes—such as endosomal transport, exosomal secretion, membrane invagination, and protein catabolism—with broad roles in cell growth, signal transduction, and disease mechanisms, particularly cancer and neurodegenerative conditions[1][2][3][7].

Other names

HGSHRSHrsZFYVE8Vps27Protein pp110ESCRT-0 subunit Hrs

Modulation of ESCRT-dependent receptor trafficking; down-regulation of receptor tyrosine kinases; endosomal/lysosomal sorting