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Target intelligence / Profile preview
Hepatocyte Membrane
- Molecular classification
- Membrane, Lipid Bilayer, Protein Complex, Transporter Complex, Receptor Complex, Junctional Complex
01
Overview
The hepatocyte membrane is the plasma membrane of hepatocytes, the main functional cells of the liver. This membrane is highly specialized and exhibits a unique polarity, being divided into distinct domains—apical (canalicular), basolateral (sinusoidal), and lateral—each with specific structural features and functions. It plays a crucial role in nutrient uptake, waste excretion, protein/lipid secretion, detoxification, and maintaining liver cell polarity. Disruption of membrane integrity and function can lead to various liver diseases.
- Other names
- Hepatocyte Plasma MembraneLiver Cell Membrane
02
Mechanism of action
Varies depending on the specific component of the membrane targeted. Examples include: Modulation of ABC transporter activity, EGFR inhibition, alteration of lipid composition.
03
Biological functions
Nutrient UptakeWaste ExcretionProtein SecretionLipid SecretionDetoxificationSelective PermeabilityEndocytosisCell-Cell AdhesionMaintenance of Cell Polarity
04
Disease associations
CholestasisCirrhosisHepatitisLiver CancerNonalcoholic Fatty Liver Disease (NAFLD)Nonalcoholic Steatohepatitis (NASH)
05
Safety considerations
HepatotoxicityDisruption of membrane integrityImpaired liver functionDrug-induced liver injury (DILI)Oxidative stress
06
Interacting drugs
Bile acids
3 more in the full profile.
07
Biomarkers
Membrane fluidityLipid peroxidation productsLevels of specific transporters or receptors in membrane fractionsIntegrity of tight junctions
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