Hepatocyte nuclear factor 4 gamma (HNF4G)

Hepatocyte nuclear factor 4 gamma (HNF4G) is a member of the nuclear receptor superfamily, functioning as a transcription factor. Encoded by the HNF4G gene, it is structurally similar to HNF4 alpha but has distinct tissue distribution—expressed in pancreas, kidney, small intestine, and testis, but largely absent in liver. HNF4G regulates gene expression involved in cell differentiation, especially in the intestinal epithelium and enterocyte lineage, and plays roles in metabolic and developmental pathways. Loss of HNF4G impairs enterocyte differentiation. It is implicated in cancer development, notably associated with poor prognosis due to its inhibition of caspase-dependent apoptosis, and is also linked to diabetes and metabolic diseases[1][2][3][4][5]. The protein is considered an orphan nuclear receptor, with some evidence for fatty acids as potential non-exchangeable endogenous co-factors rather than traditional ligand-binding[2].

Other names

Hepatocyte nuclear factor 4-gammaHNF-4-gammaNR2A2Nuclear receptor subfamily 2 group A member 2NR2A3

Modulation of gene transcription by binding to specific DNA cis-regulatory regions as a nuclear receptor/transcription factor[1][2][3]