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Target intelligence / Profile preview
Hepatocyte Organic Anion Transporting Polypeptide 1B1 (OATP1B1)
- Target
- OATP1B1
- Molecular classification
- Transporter, Solute Carrier, OATP family member
01
Overview
OATP1B1 is a membrane transporter protein primarily expressed on the basolateral (sinusoidal) membrane of human hepatocytes. It belongs to the solute carrier organic anion transporting polypeptide (OATP) family and plays a crucial role in mediating the hepatic uptake of a wide range of endogenous compounds and xenobiotics, including many clinically important drugs. Polymorphisms in SLCO1B1 can markedly affect OATP1B1 function, leading to altered drug pharmacokinetics and increased risk for adverse effects.
- Other names
- SLCO1B1
02
Mechanism of action
Facilitates Na(+)-independent transport of large amphipathic organic anions across the hepatocyte membrane.
03
Biological functions
Hepatic uptakeDrug transportAnion transportHepatic clearance
04
Disease associations
Drug response variabilityDrug-induced toxicityPharmacokinetics variations
05
Safety considerations
Statin-induced myopathyDrug-drug interactionsMethotrexate toxicity
06
Interacting drugs
Statins (e.g., simvastatin)
5 more in the full profile.
07
Biomarkers
SLCO1B1 c.521T>C (rs4149056)
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