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Target intelligence / Profile preview
Hepatocyte Organic Anion Transporting Polypeptide 1B3 (OATP1B3)
- Target
- OATP1B3
- Molecular classification
- Membrane Transporter, Transporter, Organic Anion Transporter
01
Overview
Hepatocyte Organic Anion Transporting Polypeptide 1B3 (OATP1B3) is a key membrane transporter protein predominantly expressed in human liver cells (hepatocytes). It plays a crucial role in the hepatic uptake of a wide range of endogenous and exogenous organic anions, including drugs, hormones, and their metabolites. Polymorphisms or genetic variants affecting OATP1B3 can lead to reduced transporter activity, resulting in decreased drug clearance from plasma and increased susceptibility to adverse effects. Altered tissue distribution or aberrant expression patterns have been observed in some cancers. Transport by OATP1B3 does not require ATP hydrolysis but relies on electrochemical gradients across membranes.
- Other names
- SLCO1B3OATP-8LST-3
02
Mechanism of action
Facilitated diffusion of organic anions into hepatocytes
03
Biological functions
Hepatic Uptake of Organic AnionsDrug DispositionHormone TransportBile Acid Transport
04
Disease associations
Drug-Drug InteractionsPharmacogenomicsCancer
05
Safety considerations
Statin-induced rhabdomyolysis (due to decreased drug clearance)Drug-drug interactions (due to competition for transport)
06
Interacting drugs
Statins
2 more in the full profile.
07
Biomarkers
OATP1B3 polymorphisms
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