Hepatocyte protection pathways

Hepatocyte protection pathways" collectively refers to a network of signaling mechanisms that preserve hepatocyte viability and support liver regeneration and repair following various injuries, including toxic, infectious, autoimmune, or ischemic insults. Key pathways include cytokine signaling (such as IL-6–gp130–STAT3), growth factor signals (Hepatocyte growth factor, Epidermal growth factor, FGF), Wnt/β-catenin, PI3K-AKT-mTOR, Hippo, and others[1][2][3][4][5][7]. These processes modulate inflammation, apoptosis, proliferation, metabolism, and fibrotic response and are fundamental for maintaining liver health and enabling recovery after damage. While each pathway may contain specific druggable targets (such as IL-6 receptor, HGF receptor [MET], or β-catenin), "hepatocyte protection pathways" itself is not used as a single molecular or therapeutic target in biology or medicine.