Hepatocyte replacement (null)

Hepatocyte replacement refers to therapeutic strategies aimed at substituting diseased or dysfunctional liver cells (hepatocytes) with functional hepatocytes, typically by transplantation. This approach partially restores hepatic metabolic, synthetic, and detoxification capacity in patients with inherited metabolic liver diseases, acute liver failure, or select conditions where full organ transplantation is undesirable or infeasible. Unlike liver transplantation, hepatocyte transplantation is less invasive, may be repeated, and does not require removal of the native organ, but its clinical efficacy is often limited by immune rejection, poor cell engraftment, and limited cell supply.

Other names

Hepatocyte transplantationhepatocyte therapyliver cell therapyhepatocyte replacement therapy

Functional replacement of diseased/dysfunctional hepatocytes with healthy ones; Restoration/compensation of lost metabolic and synthetic functions of the liver