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Target intelligence / Profile preview
Hepatoma-derived growth factor-like 1 (HDGFL1)
- Target
- HDGFL1
- Molecular classification
- Other (chromatin-associated protein)
01
Overview
Hepatoma-derived growth factor-like 1 (HDGFL1) is a nuclear protein predicted to be involved in chromatin remodeling and is active in the nucleus[1][5]. It is related to the hepatoma-derived growth factor (HDGF) protein family but does not appear to have a well-characterized function as a classical therapeutic target; current evidence suggests roles in iron homeostasis and reproductive biology based on genetic associations, but its precise molecular functions remain incompletely understood[1][5]. HDGFL1 contains a PWWP domain, which is often implicated in chromatin binding and regulation. No direct drug interactions or established biomarker roles are currently described for this protein[1][5][2].
- Other names
- HRP-1Hdgfrp1PWWP1dJ309H15.1PWWP domain-containing protein 1testicular tissue protein Li 84
02
Biological functions
Chromatin remodelingNuclear activity(Potential) transcriptional regulation
03
Disease associations
Other (potential roles in iron metabolism and reproductive function suggested by GWAS; no strong disease linkage established)
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