Target intelligence / Profile preview

Hepatoma-derived growth factor-related protein 2 (HDGFL2)

Target: HDGFL2
Molecular classification: Other (HDGF family, chromatin-binding protein, contains PWWP domain)

Overview

Hepatoma-derived growth factor-related protein 2 (HDGFL2) is a member of the HDGF family that contains an N-terminal PWWP domain, enabling it to bind specifically to methylated histones such as tri-methylated lysines 36 and 79 of histone H3 and di- and tri-methylated lysine 20 of histone H4. It acts as an epigenetic regulator of myogenesis, associates with the BAF chromatin-remodeling complex, promotes DNA double-strand break repair through homologous recombination, and determines the site of HIV-1 integration independent of LEDGF/p75. HDGFL2 is implicated in cellular growth control, particularly through cyclin D1 expression, and diseases related to its dysfunction include neurodegenerative disorders such as frontotemporal dementia and amyotrophic lateral sclerosis. There are currently no drugs known to target HDGFL2, and no established biomarker or safety profile in a therapeutic context.

Other names: HDGF like 2HDGF-2HDGFRP2HRP-2MGC2641Similar to hepatoma-derived growth factor-related protein 2HRP2HDGF2HDGF-related protein 2Hdgfrp2

Biological functions

Chromatin bindingDNA repair (homologous recombination pathway)Positive regulation of cell growthEpigenetic regulation of myogenesisSelection of HIV-1 integration sites

Disease associations

Neurodegenerative disease (Frontotemporal dementia and/or amyotrophic lateral sclerosis)Potential association with cancer (hepatocellular carcinoma, based on overexpression)

Beyond the preview

Go deeper on Hepatoma-derived growth factor-related protein 2 (HDGFL2).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Hepatoma-derived growth factor-related protein 2 (HDGFL2).

Explore the full profile