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Hepsin
- Molecular classification
- Type II transmembrane serine protease, Enzyme
01
Overview
Hepsin, also known as TMPRSS1, is a type II transmembrane serine protease primarily expressed in the liver, but also found in other tissues like the kidney, lung, and adipose tissue. It plays a crucial role in physiological homeostasis and is implicated in cancer progression and metabolic regulation. It activates growth factors like HGF and MST1, modulates adipocyte differentiation, and affects urinary protein processing. Hepsin is overexpressed in some cancers, particularly prostate cancer, making it a potential biomarker.
- Other names
- TMPRSS1
02
Mechanism of action
Serine protease activity, cleaving extracellular substrates
03
Biological functions
Growth factor activation/processingMetabolic regulationCoagulation initiationUrinary secretion modulationAdipocyte differentiationAuditory function
04
Disease associations
CancerMetabolic disordersRenal dysfunctions
05
Biomarkers
Prostate cancer biomarker
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