Target intelligence / Profile preview

Heptad Repeat 1 Domain of Spike Glycoprotein (HR1)

Target: HR1
Molecular classification: Viral Fusion Protein Domain, Coiled-coil protein

Overview

The heptad repeat 1 (HR1) domain is a highly conserved region within the S2 subunit of the coronavirus spike (S) glycoprotein. The spike protein is a class I viral fusion protein responsible for mediating entry of coronaviruses into host cells. The HR1 domain plays a critical role in the membrane fusion process that allows viral genetic material to enter host cells. It forms an α-helical trimeric coiled-coil motif and interacts with the HR2 domain to form a six-helix bundle, essential for merging viral and host cell membranes.

Other names: HR1 domainHeptad Repeat 1S2 HR1

Mechanism of action

Block virus-cell membrane fusion by disrupting six-helix bundle formation

Biological functions

Membrane fusionViral entrySix-helix bundle formation

Disease associations

Infection

Interacting drugs

Peptide-based inhibitors

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