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Heptad Repeat 2 Domain of Spike Glycoprotein
- Molecular classification
- Viral Protein Domain, Coiled-coil Domain, Fusion Peptide Component
01
Overview
The heptad repeat 2 (HR2) domain is a conserved region within the S2 subunit of the coronavirus spike (S) glycoprotein. The spike protein is a class I viral fusion protein responsible for mediating viral entry into host cells by facilitating membrane fusion. The HR2 domain, together with heptad repeat 1 (HR1), plays a critical role in this process. During virus-cell entry, conformational changes in the spike protein bring together the HR1 and HR2 domains to form a six-helix bundle structure. This structural rearrangement brings viral and cellular membranes into close proximity, enabling their fusion—a critical step for viral genome delivery into host cells. It is a target for antiviral strategies and vaccine design.
- Other names
- HR2 DomainHeptad Repeat 2HR2 of SARS-CoV-2 Spike ProteinHR2 of Coronavirus Spike Glycoprotein
02
Mechanism of action
Inhibition of six-helix bundle formation, disruption of virus-cell membrane fusion
03
Biological functions
Virus-host cell membrane fusionSix-helix bundle formationViral entry
04
Disease associations
InfectionCOVID-19SARSMERS
05
Interacting drugs
HR2-derived peptides
1 more in the full profile.
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